Barcelona will host Real Sociedad on the opening weekend of the 2021-22 La Liga season, while Real Madrid will tour Alavés on the weekend of October 24 with the first Clasico of the campaign, the Spanish Football Federation (RFEF) announced.
Champions Atletico Madrid, meanwhile, will begin their La Liga title defense at Celta Vigo.
Real Madrid will play their first three matches away from home due to ongoing construction work at their Santiago Bernabeu stadium, with their first home match against Celta on the weekend of 12 September.
Barca will host Real Madrid at Camp Nou on matchday 10 on the weekend of 24 October, before the return fixture at the Bernabeu on match day 29, on the weekend of 20 March.
The 2021–22 La Liga season will be the first to be broadcast on ESPN+ in the United States after ESPN agreed a new eight-year deal for the English and Spanish language rights starting in August 2021. Every La Liga match will be live. On ESPN+ as well as some Second Division matches.
The calendar was revealed on Wednesday at the RFEF's headquarters in Madrid, with the fixture list chosen at random from a set of predetermined options.
The 2021–22 season will begin on the weekend of August 15, 2021 and conclude on the weekend of May 22, 2022. Whereas the day and time of matches - with games taking place every weekend between Friday and Monday - will be selected. by La Liga at a later date.
The Spanish government announced last week that it was lifting a ban on fans attending matches in the first and second divisions, as all of the previous season was played behind closed doors, although attendance would still be limited by regional health restrictions.
La Liga president Javier Tebas has said he expects stadiums to be at least 70% full for the start of the season, with the potential to be 100% capacity by November.
Real Madrid will travel to Alaves, Levante and Real Betis in their opening three games of the campaign, with coach Carlo Ancelotti in charge for their second spell after the resignation of Zinedine Zidane.
Sources told ESPN last month that the club preferred to start the season with three consecutive away games to give the Bernabeu time to prepare to host fans, rather than considering options such as Atletico's use of Wanda Metropolitano.
Real Madrid and Barca were held by Atletico in a tense climax to the La Liga title in 2020-21, with the race going to the final day of the season.
Atletico finished on 86 points, two points ahead of local rivals Real Madrid and seven points ahead of Barca, after a dramatic 2-1 final day comeback at Real Valladolid.